Combining naproxen and prednisone significantly increases your risk of stomach ulcers and bleeding. Naproxen, a nonsteroidal anti-inflammatory drug (NSAID), irritates the stomach lining. Prednisone, a corticosteroid, further weakens this lining. This combination creates a potent effect, making you far more susceptible to gastrointestinal problems.
Minimizing Risk
To reduce your risk, consider these strategies:
| Take medication with food | Food helps buffer the stomach lining from the irritating effects of these drugs. |
| Use a proton pump inhibitor (PPI) | Your doctor might prescribe a PPI, like omeprazole or lansoprazole, to reduce stomach acid production and protect your stomach lining. |
| Monitor for symptoms | Pay close attention to any signs of gastrointestinal distress, including heartburn, nausea, vomiting, or black, tarry stools. |
When to Seek Medical Attention
Contact your doctor immediately if you experience severe stomach pain, vomiting blood, or black, tarry stools. These are serious signs and require prompt medical attention.
Alternative Medications
Discuss alternative pain relief options with your doctor. They may suggest different medications that pose a lower risk of gastrointestinal complications.
